We present a novel, universal architecture for a cascade linear symmetric fully differential amplifier. It is applicable to all implementation sets of complementary pair devices such as BJT, JFET, MOSFET. The presented examples demonstrate the superiority of the proposed circuit over the existing solutions. Comparison of the proposed and the traditional differential amplifier is done under the same quiescent conditions and with the same set of complementary npn-pnp devices. Characteristics are illustrated in frequency and time domain, and it is also given linearity error of voltage transfer characteristic amplifier. A common mode gain of the proposed amplifier with a double-ended output is negligible because the new structure is inherently fully symmetric. Prospective applications of the proposed amplifier include permanent monitoring of the natural phenomena, audio signals of speech and music, and also various signals in medicine, pharmacy, science, technique and other areas. Linearity error of the static voltage transfer characteristic of the novel amplifier is 0.0072 mV for 1 Vpp of the output signal. Classical amplifier produces significantly higher linearity error of 19.24 mV for output voltage swing of 0.86 Vpp. Proposed design strategy of operational amplifiers employing new complete fully differential amplifier will have application in processing of differential real signal in s domain and also real and complex sequences in z domain, special audio and RF signal.